Restless Leg Syndrome Induced by an Acute Withdrawal of Oxycodone
نویسنده
چکیده
Restless leg syndrome (RLS) is a common movement disorder, which disturbs sleep and consequently results in reduced daytime functioning. Alteration in nigral iron deposition and dysfunction of dopaminergic modulation is generally thought to be the main underlying pathophysiology of RLS.1 Oxycodone, a semisynthetic opioid, is one of the treatment options for severe RLS. Its analgesic effect is mediated by k-opioid receptor or μ-opioid receptor which is not clearly identified yet.2 Oxycodone shares many common pharmacological mechanisms with other opioids. There are some reports that abrupt withdrawal of some opioids can induce RLS. Therefore, abrupt withdrawal of oxycodone is expected to induce RLS. However, RLS has never been reported as a withdrawal symptom of oxycodone. We reported a case of secondary RLS, which developed after abrupt withdrawal of oxycodone in a patient with hepatocellular carcinoma associated with severe abdominal pain.
منابع مشابه
Oxycodone/Naloxone PR: A Review in Severe Refractory Restless Legs Syndrome.
An oral, fixed-dose combination of prolonged-release (PR) oxycodone with PR naloxone (Targin(®), Targiniq(®), Targinact(®); hereafter referred to as oxycodone/naloxone PR) is approved in Europe for the second-line symptomatic treatment of patients with severe to very severe idiopathic restless legs syndrome (RLS), after failure of dopaminergic therapy. Coadministration of naloxone represents a ...
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